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- Sacriston - 1 Company
- Saffron Walden - 129 Companies
- Salcombe - 6 Companies
- Sale - 96 Companies
- Salford - 291 Companies
- Salford Quays - 1 Company
- Salisbury - 165 Companies
- Saltash - 33 Companies
- Saltburn-by-the-Sea - 18 Companies
- Saltcoats - 4 Companies
- Saltford - 1 Company
- Sambourne - 1 Company
- Sandbach - 80 Companies
- Sandhurst - 49 Companies
- Sandown - 17 Companies
- Sandwich - 19 Companies
- Sandy - 116 Companies
- Sanquhar - 2 Companies
- Saundersfoot - 1 Company
- Sawbridgeworth - 46 Companies
- Sawston - 7 Companies
- Sawtry - 1 Company
- Saxilby - 1 Company
- Saxmundham - 21 Companies
- Scarborough - 98 Companies
- Scarisbrick - 1 Company
- Scraptoft - 1 Company
- Scunthorpe - 204 Companies
- Seaford - 18 Companies
- Seaham - 26 Companies
- Seahouses - 1 Company
- Seaton - 4 Companies
- Seaton Delaval - 3 Companies
- Sedbergh - 6 Companies
- Sedgefield - 2 Companies
- Sedgley - 3 Companies
- Selby - 61 Companies
- Selkirk - 19 Companies
- Settle - 4 Companies
- Sevenoaks - 245 Companies
- Severn Stoke - 1 Company
- Shaftesbury - 28 Companies
- Shanklin - 8 Companies
- Sharnford - 1 Company
- Sharpness - 3 Companies
- Sharpthorne - 1 Company
- Shaw - 1 Company
- Sheerness - 34 Companies
- Sheffield - 1304 Companies
- Shefford - 63 Companies
- Shenstone - 1 Company
- Shepperton - 38 Companies
- Shepshed - 15 Companies
- Shepton Mallet - 35 Companies
- Sherborne - 21 Companies
- Sheringham - 2 Companies
- Shetland - 22 Companies
- Shetland Mainland - 1 Company
- Shevington - 1 Company
- Shifnal - 37 Companies
- Shildon - 28 Companies
- Shildon County - 1 Company
- Shilton - 2 Companies
- Shipley - 80 Companies
- Shipston on Stour - 1 Company
- Shipston-on-Stour - 15 Companies
- Shipton-under-Wychwood - 1 Company
- Shirebrook - 5 Companies
- Shirley - 8 Companies
- Shoeburyness - 9 Companies
- Shoreham - 9 Companies
- Shoreham By Sea - 2 Companies
- Shoreham-by-Sea - 41 Companies
- Shorne - 1 Company
- Shotton - 4 Companies
- Shotts - 17 Companies
- Shrewsbury - 244 Companies
- Sidcup - 82 Companies
- Siddal - 1 Company
- Sidmouth - 10 Companies
- Silchester - 1 Company
- Silkstone - 1 Company
- Silloth - 2 Companies
- Silsden - 5 Companies
- Silverstone - 1 Company
- Silverton - 1 Company
- Simonstone Burnley - 1 Company
- Sittingbourne - 199 Companies
- Skegness - 33 Companies
- Skelmersdale - 139 Companies
- Skelmorlie - 2 Companies
- Skelton - 1 Company
- Skene - 2 Companies
- Skipton - 67 Companies
- Sleaford - 57 Companies
- Slough - 410 Companies
- Small Dole - 1 Company
- Small Heath - 2 Companies
- Smallfield - 4 Companies
- Smethwick - 164 Companies
- Snodland - 18 Companies
- Sockport - 1 Company
- Soham - 1 Company
- Solihull - 297 Companies
- Somercotes - 4 Companies
- Somersham - 2 Companies
- Somerton - 22 Companies
- Sonning - 1 Company
- South Ascot - 1 Company
- South Bank - 1 Company
- South Brent - 9 Companies
- South Cave - 1 Company
- South Croydon - 33 Companies
- South Godstone - 7 Companies
- South Harrow - 1 Company
- South Milford - 1 Company
- South Molton - 19 Companies
- South Newmoor Ind Est - 1 Company
- South Norwood - 1 Company
- South Nutfield - 3 Companies
- South Ockendon - 39 Companies
- South Petherton - 8 Companies
- South Queensferry - 7 Companies
- South Ronaldsay - 1 Company
- South Ruislip - 1 Company
- South Shields - 97 Companies
- South Woodham Ferrers - 13 Companies
- Southall - 67 Companies
- Southam - 49 Companies
- Southampton - 769 Companies
- Southend - 13 Companies
- Southend on Sea - 4 Companies
- Southend-on-Sea - 188 Companies
- Southgate - 1 Company
- Southminster - 9 Companies
- Southport - 178 Companies
- Southsea - 28 Companies
- Southwark - 2 Companies
- Southwell - 15 Companies
- Southwick - 3 Companies
- Southwold - 4 Companies
- Sowerby Bridge - 55 Companies
- Spalding - 139 Companies
- Spean Bridge - 1 Company
- Speen - 1 Company
- Speke - 2 Companies
- Spennymoor - 22 Companies
- Spilsby - 19 Companies
- Spratton - 1 Company
- St Agnes - 1 Company
- St Albans - 18 Companies
- St Asaph - 1 Company
- St Austell - 7 Companies
- St Cleer - 1 Company
- St Helens - 11 Companies
- St Ives - 4 Companies
- St Leonards on Sea - 1 Company
- St Leonards-on-Sea - 4 Companies
- St Neots - 10 Companies
- St Pauls - 1 Company
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